Abstract
Six cases of epilepsy and ring chromosome 20 are reported and 20 additional cases in the literature are reviewed from the National Epilepsy Center, Shizuoka Higashi Hospital, Japan.
Highlights
GENETICS OF EPILEPSIES WITH FOCAL SHARP WAVES The clinical manifestations and genetic aspects in 147 children with benign focal sharp waves were evaluated at the Epilepsy Center, Raisdorf, Germany
Stereotactic radiofrequency surgical treatment of the hamartoma of one patient resulted in seizure remission. (Kuzniecky R, Guthrie B, Mountz J et al Ann Neurol July 1997;42:60-67)
Gelastic ('gelos' Gr for mirth) seizures in children with precocious puberty and hypothalamic hamartoma originate from the hamartoma and involve adjacent diencephalic areas
Summary
GENETICS OF EPILEPSIES WITH FOCAL SHARP WAVES The clinical manifestations and genetic aspects in 147 children with benign focal sharp waves were evaluated at the Epilepsy Center, Raisdorf, Germany. GELASTIC EPILEPSY AND HYPOTHALAMIC HAMARTOMA Three patients with hypothalamic hamartoma and gelastic seizures were studied using ictal single-photon emission computed tomography and EEG recordings with depth electrodes at the University of Alabama at Birmingham Epilepsy Center. Precocious puberty developed by age 7, and the patients were large for their age, above the 95th percentile. Laughing seizures began in the newborn period in 2 patients and before 6 years in a third. The frequency of attacks ranged from 1 to 5 minor episodes daily to 10 complex partial seizures each month.
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