Abstract
Given the unknown long-term consequences of gadolinium deposition in neural and other tissues and the high cost of dynamic contrast-enhanced (DCE) MRI, there is emerging interest in noncontrast-enhanced breast MRI. Diffusion-weighted (DW) MRI is a fast, unenhanced technique that can illustrate breast malignancy based on reduced water diffusivity in tumors compared to normal tissue. The use of DW MRI as both adjunct and alternative modality to DCE-MRI in breast cancer detection, prognosis, and treatment response has been widely explored. In cancer detection, current evidence suggests that stand-alone DW MRI provides higher sensitivity than that of mammography but lower sensitivity than that of DCE-MRI. Emerging advanced DW MRI acquisition, postprocessing, and modeling may further improve the performance of DW MRI in breast imaging.
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