Abstract
A novel multi-view non-contact dynamic diffuse optical tomographic imaging system for the clinical evaluation of vasculature in the lower extremities is presented. The system design and implementation are described in detail, including methods for simultaneously obtaining and reconstructing diffusely reflected and transmitted light using a system of mirrors and a single CCD camera. The system and its performance using numeric simulations and optical phantoms. Measurements of a healthy foot in vivo demonstrates the potential of the system in assessing perfusion within the foot.
Highlights
Diffuse optical imaging (DOI) systems have been developed for clinical applications such as breast cancer [1,2,3,4,5], arthritis [6,7,8], brain function [9, 10], and vascular diseases [11,12,13]
We have previously shown that dynamic diffuse optical tomography (DDOT) has great potential for detecting peripheral arterial disease (PAD) by extracting time-dependent features of the total hemoglobin concentrations in the foot during a venous occlusion at the thigh [11, 12]
The mean ∆[HbT] within the region of interest (ROI) of each angiosome is plotted over time in Fig. 13(b), with the dorsalis pedis artery (DPA) shown in blue, the medial plantar artery (MPA) shown in orange, and the lateral plantar artery (LPA) shown in green
Summary
Diffuse optical imaging (DOI) systems have been developed for clinical applications such as breast cancer [1,2,3,4,5], arthritis [6,7,8], brain function [9, 10], and vascular diseases [11,12,13]. Like many other traditional DDOT imaging systems, our previous system employed optical fibers in direct contact with the tissue surface to deliver and collect light [11, 12] We found that this limits its clinical utility, especially in patients with open wounds and ulcers, which is a common occurrence in PAD patients. The system was tested on a healthy foot during a venous occlusion and was able to provide spatial maps of hemodynamic changes From these time-varying maps, we can extract functional information about the lower extremity vasculature, which may be very useful in evaluating diseases such as PAD
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