Abstract
High resolution yttrium-90 (90Y) imaging of post-radioembolization microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT) scanners that have time-of-flight capability. However, reconstructed 90Y PET/CT images have high background noise, making non-target activity detection technically challenging. This educational article describes our image assessment technique for non-target activity detection by 90Y PET/CT, which qualitatively overcomes the problem of background noise. We present selected case examples of non-target activity in untargeted liver, stomach, gallbladder, chest wall, and kidney, supported by angiography and 90Y bremsstrahlung single-photon emission computed tomography with integrated computed tomography (SPECT/CT) or technetium-99m macroaggregated albumin SPECT/CT.
Highlights
Radioembolization (RE) is brachytherapy by arterially injected yttrium-90 (90Y) microspheres for the treatment of malignancies
High resolution 90Y imaging of post-RE microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT) scanners that have time-of-flight capability [1]
We developed an image assessment technique for non-target activity detection by 90Y PET/CT, which qualitatively overcomes the problem of background noise
Summary
Radioembolization (RE) is brachytherapy by arterially injected yttrium-90 (90Y) microspheres for the treatment of malignancies. High resolution 90Y imaging of post-RE microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT) scanners that have time-of-flight capability [1]. The presence of non-target activity may have clinical implications for radiomicrosphere toxicity and is as important as target activity detection.
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