Abstract
The dermal absorption of amethocaine from percutaneous local anaesthetic preparations has been monitored in a panel of 10 volunteers using laser-Doppler velocimetry (LDV). LDV is a non-invasive technique which responds to increased perfusion in the cutaneous microcirculation. The study was fully randomised and double-blinded. A standard regimen involving a 30 min application time for the preparations was followed in all cases. Statistical analysis of the LDV results was made using one-way analysis of variance and the Newman-Keuls multiple-range test. A significant increase in peak blood cell flux resulted from application of the formulations, correlating with an increase in the drug concentration. In all cases the increased perfusion was significantly different from placebo. The time at which the peak flux occurred was in good agreement with the previously determined mean onset times for anaesthesia with these preparations. However, the area under the perfusion curve was not a reliable indicator of the duration of anaesthesia. The transient erythema occasionally observed with amethocaine percutaneous anaesthetic preparations was confirmed as a pharmacological property of the drug rather than a slight side-effect of the formulation.
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