Abstract
Many diabetic mellitus patients envision a non-invasive method of blood glucose measurement since they require periodic monitoring of their blood glucose levels to ensure that it is stable and within the normal range. In this study, we detected glucose concentration using commercial light emitting diodes (LEDs) with a wavelength of 700–1600 nm. Light of long wavelengths (e.g. NIR) infiltrate human skin and reach the blood vessel lining, thereby aiding in the non-invasive measurement of blood glucose concentration. To demonstrate this, the concentration of glucose solutions was measured using red and NIR-LEDs in a non-invasive manner. The sensitivity of glucose detection was greater when light of wavelength below 1000 nm was used, owing to the absorption of wavelengths above 1000 nm by water. Furthermore, we controlled the input current of the red and NIR-LEDs to confirm the light intensity deviation with increasing glucose concentrations and suggested the optimum wavelength of light using this in-vitro system. Among various LEDs, the 700 nm LED showed higher light intensity deviation with change in injection current compared to LEDs with the other wavelengths. In particular, compared to other LEDs, a stark difference was observed in the light intensity of the 700 nm LED while measuring glucose concentrations in the range of 50–100 mg/dl.
Highlights
Diabetes mellitus is one of the significant public health issues affecting more than 400 million people worldwide
We measured the intensity of light transmitted through glucose solutions of various concentrations using red and NIR-light emitting diodes (LEDs) and a light detector to measure the amount of injection current
Red and NIR-LEDs of different wavelengths less than 1000 nm were used as the light source, and the amount of light transmitted light through glucose solutions of different concentrations was measured using a spectrophotometer
Summary
Diabetes mellitus is one of the significant public health issues affecting more than 400 million people worldwide. Diabetic patients usually use a glucose meter to measure the blood glucose level This is an invasive detection method involving the pricking of fingers using a lancet to obtain a few drops of blood [7,8,9,10], which is placed on a stripe and inserted into the glucose meter. Near-Infrared Light-Emitting Diodes introduced to measure blood glucose levels These serve as an excellent alternative to the glucose meter, which involves removing a few drops of blood. We determined the concentrations of various glucose solutions using commercial red and near-IR (NIR)-light-emitting diodes (LEDs) in the wavelength of. The output light intensity of the red and NIR LEDs after passage through the different glucose solutions was recorded to determine the correlation between the measured value and the expected glucose concentration
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