Non-functional urinary bladder paraganglioma with negative Ga-DOTA-NOC PET/CT uptake

Linda Kalliath,Nivedita Chandran,Gokul Kripesh,Banumathi Ramakrishna,D Karthikeyan

doi:10.1186/s43055-021-00671-2

Linda Kalliath, Nivedita Chandran + Show 3 more

Open Access

https://doi.org/10.1186/s43055-021-00671-2

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Abstract

BackgroundParaganglioma of the urinary bladder is a very rare benign tumor that constitutes less than 0.5% of all bladder tumors. It can be functional and non-functional. Functional tumors present with symptoms of catecholamine excess, and non-functional tumors usually remain asymptomatic.Case presentationHere, we present a case of non-functional urinary bladder paraganglioma in a 36-year-old female who presented to us with a history of intermittent hematuria. The routine hematological and biochemical parameters were within normal limits. Diagnostic computed tomography (CT) revealed a hypervascular lesion in the urinary bladder dome with no significant uptake in gallium-68-labelled-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid peptides-NaI3-octreotide positron emission tomography (DOTA-NOC PET/CT). Histopathology and immunohistochemistry confirmed the diagnosis of paraganglioma.ConclusionWe present this case because of the rare location of paraganglioma in the urinary bladder and being non-functional with low/absent somatostatin receptor expression.

Highlights

ConclusionWe present this case because of the rare location of paraganglioma in the urinary bladder and being non-functional with low/absent somatostatin receptor expression
Paraganglioma of the urinary bladder is a very rare benign tumor that constitutes less than 0.5% of all bladder tumors
Urinary bladder paraganglioma is a very rare tumor that constitutes less than 0.5% of all bladder tumors

Summary

Conclusion

Urinary bladder paraganglioma is a benign tumor mostly seen in adults presented with symptoms of catecholamine excess. The presence of a highly vascular hyperenhancing lesion with absent washout and elevated catecholamine metabolites combined with clinical manifestations should raise the suspicion of paraganglioma. In the case of non-functional paraganglioma, histopathology and immunohistochemistry aid in the diagnosis. We present this case because of its rare location in the urinary bladder and present a non-functional paraganglioma with low/absent somatostatin receptor expression

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