Clinicopathologic analyses of 6 cases of paraganglioma of urinary bladder

Abstract

Objective To investigate the clinicopathological features, diagnosis and treatment of paraganglioma of urinary bladder (PUB). Methods The clinicopathological and follow-up data of 6 patients with paraganglioma of urinary bladder treated during November 2008 and July 2018 in our hospital were retrospectively analyzed. Results The six cases involved 1 males and 5 females with the average age of 42 (23-55) years. All cases were nonfunctional neoplasm. All the lesions were solitary with an average diameter of 1.6 (0.8-2.2) cm. One case had the symptom of urodynia, the other 5 cases were asymptomatic. CT scan was significantly enhanced. One case underwent laparoscopic partial cystectomy, one case underwent partial cystectomy, and the other 4 cases underwent transurethral resection of bladder tumor (TURBT). The average duration of operation was 72 (35-130) min. The average estimated blood loss was 22 (10-50) ml. Immunohistochemistry showed neuroendocrine markers (e.g. CgA, CD56 and Syn) were expressed in all cases, while epithelial markers (e.g. CK, CEA) were negative. During the follow-up of 8 months to 11 years, one patient suffered from recurrent tumor 5 years after initial TURBT. The other five cases had no recurrence or metastasis. Conclusions PUB is a rare tumor which has no obvious symptoms. A definite diagnosis can be made by CT scan combined with immunohistochemistry. TURBT was safe and effective. The life-long follow-up of these lesions was indispensable. Key words: Bladder; Paraganglioma; Clinicopathological features; Treatment