Abstract
Objective: The aim of the study was to evaluate the association between non-dipping pattern of systolic BP (SBP) in sinus rhythm individuals. Design and method: We studied 145 individuals (mean age, 60 [95% CI, 59–62] years, 54% men), 92% was essential hypertension patients, who underwent 24-h ABPM and 24-h ECG. Averages were measured for SBP, diastolic (DBP), pulse pressure (PP), mean arterial pressure (MAP) and 24-h ambulatory arterial stiffness index (AASI) calculated. According to the degree of nocturnal SBP fall (according to the 24-hour-clock-based definition of night from 1 am to 6 am), patients were sub-classified as dippers (39%) and non-dippers (61%), which included mild dippers (60/89), extreme dippers (6/89), reverse dippers (23/89). A bivariate multivariate logistic regression analysis (Stata 15) was performed to evaluate the value of ABPM parameters for non-dipping status. Results: Comparisons between groups showed no differences in age, sex, as well as in SBP, DBP, PP, MAP. The best fitting model for explanatory non-dipping pattern (log likelihood = -97.82; AUC ROC = 0.6372) after adjustment for age, sex (male vs female), SBP, DBP, PP, MAP with ORs included AASI (11.57 [CI 95%, 1.02–130.47], p = 0.048). Conclusions: 24-h AASI is the only one ABPM parameter that associated with non-dipping pattern in individuals with sinus rhythm.
Published Version
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