Non-Destructive Real-Time Glucose Quantification Using 5-Turn Meandered Signal Coplanar Sensor Integrated with Circular PDMS Cavity

Abstract

In this paper, the experimental demonstration in the prospective application of the novel label-free microwave-based Meandered Signal Coplanar Sensor (MSCS), for the non-destructive quantification of the glucose in aqueous solution, has been presented. The sensor has been designed by embedding 5-turn meander inductor in the signal conductor of a 50 Ω coplanar waveguide (CPW) transmission line, where the sensing area is configured with Polydimethylsiloxane (PDMS). Precursory modelling of the CPW transmission line and the meander inductor have been executed in MATLAB and further optimization has been carried out in 3D CST Microwave Studio Suite 2017 simulator. The experimentally measured magnitude and peak frequency for S11 and S21, respectively, showed good sensitivity of 18.42 dB/g/ml, 265.72 MHz/g/ml, 36.51 dB/g/ml and 1050 MHz/g/ml, respectively. The regression analysis with high linearity of 0.921, 0.944, 0.762, and 0.839, respectively, validated the correlation of the glucose concentration with the magnitude and peak frequency of the S-parameters.