Abstract
Non-contrast cardiac MRI for tissue characterization in patients with end stage renal disease
Highlights
End stage renal disease (ESRD) patients suffer high cardiovascular mortality rates with fibrosis-induced arrhythmia recognized as a leading contributor
While septal wall thickness was heightened in ESRD patients (Table 1), ejection fraction and peak circumferential and longitudinal strains were similar to controls
A sample ΔS/So map in an ESRD patient (Figure 1E) demonstrates scattered enhancement compared to a healthy control (Figure 1D)
Summary
End stage renal disease (ESRD) patients suffer high cardiovascular mortality rates with fibrosis-induced arrhythmia recognized as a leading contributor. Since ESRD patients are contraindicated to standard gadolinium-based fibrosis imaging, non-contrast cardiac magnetic resonance imaging (CMR) techniques could improve diagnosis and empower evaluation of emerging anti-fibrotic therapies. With remodeling and increased extracellular water volume, a corresponding and measurable loss of magnetization transfer (MT) occurs. We previously demonstrated the ability to identify tissue that enhances with gadolinium based on differences between pairs of differentially MTweighted balanced steady state free precession (bSSFP) images[1,2] (Figure 1A-C). We seek to apply non-contrast MT-based tissue characterization in ESRD patients
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