Non Celiac Gluten Sensitivity-exploring the New Entity

Abstract

BackgroundSpectrum of gluten-related disorders got a new entity, represented by gluten sensitivity. Clinical picture is a combination of IBS (irritable bowel syndrome) symptoms and of systemic manifestations. No strict criteria for the diagnosis of NCGS exist, prevalence claimed to be up to 6%.ObjectivesTo study the prevalence of non-celiac gluten sensitivity (NCGS) and response to dietary intervention in IBS.Subjects and Methods90 patients between 18 to 65 years, with a diagnosis of IBS as per Rome III criteria, were included. Celiac disease and wheat allergy were excluded appropriately. Patients fulfilling the inclusion criteria were given gluten free diet for 4 weeks and patients followed weekly. The patients were interviewed for symptoms at baseline and weekly for 4 weeks, and compared on 100 mm visual analogue scale. Study population was again given normal gluten containing diet to look for reappearance of the symptoms. Analysis of quantitative data measured 3 times (baseline, 1 month after GFD after re-challenge) was done using Friedman RM ANOVA on Ranks and Appropriate Post Hoc test was used.ResultsMales outnumbered the females in the study. On a visual analogue scale, 3 patients showed significant improvement with gluten free diet for overall symptoms (P < .05), pain (P < .05), bloating P < .05), satisfaction with stool consistency (P < .05). On gluten rechallenge after completion of 4 weeks, patient symptom deterioration occurred in days to week duration.ConclusionsOur data identifies a patient population suffering from non-celiac gluten sensitivity.LimitationsRandomized double-blind placebo controlled study would have been better approach. The present study is limited with low sample size. BackgroundSpectrum of gluten-related disorders got a new entity, represented by gluten sensitivity. Clinical picture is a combination of IBS (irritable bowel syndrome) symptoms and of systemic manifestations. No strict criteria for the diagnosis of NCGS exist, prevalence claimed to be up to 6%. Spectrum of gluten-related disorders got a new entity, represented by gluten sensitivity. Clinical picture is a combination of IBS (irritable bowel syndrome) symptoms and of systemic manifestations. No strict criteria for the diagnosis of NCGS exist, prevalence claimed to be up to 6%. ObjectivesTo study the prevalence of non-celiac gluten sensitivity (NCGS) and response to dietary intervention in IBS. To study the prevalence of non-celiac gluten sensitivity (NCGS) and response to dietary intervention in IBS. Subjects and Methods90 patients between 18 to 65 years, with a diagnosis of IBS as per Rome III criteria, were included. Celiac disease and wheat allergy were excluded appropriately. Patients fulfilling the inclusion criteria were given gluten free diet for 4 weeks and patients followed weekly. The patients were interviewed for symptoms at baseline and weekly for 4 weeks, and compared on 100 mm visual analogue scale. Study population was again given normal gluten containing diet to look for reappearance of the symptoms. Analysis of quantitative data measured 3 times (baseline, 1 month after GFD after re-challenge) was done using Friedman RM ANOVA on Ranks and Appropriate Post Hoc test was used. 90 patients between 18 to 65 years, with a diagnosis of IBS as per Rome III criteria, were included. Celiac disease and wheat allergy were excluded appropriately. Patients fulfilling the inclusion criteria were given gluten free diet for 4 weeks and patients followed weekly. The patients were interviewed for symptoms at baseline and weekly for 4 weeks, and compared on 100 mm visual analogue scale. Study population was again given normal gluten containing diet to look for reappearance of the symptoms. Analysis of quantitative data measured 3 times (baseline, 1 month after GFD after re-challenge) was done using Friedman RM ANOVA on Ranks and Appropriate Post Hoc test was used. ResultsMales outnumbered the females in the study. On a visual analogue scale, 3 patients showed significant improvement with gluten free diet for overall symptoms (P < .05), pain (P < .05), bloating P < .05), satisfaction with stool consistency (P < .05). On gluten rechallenge after completion of 4 weeks, patient symptom deterioration occurred in days to week duration. Males outnumbered the females in the study. On a visual analogue scale, 3 patients showed significant improvement with gluten free diet for overall symptoms (P < .05), pain (P < .05), bloating P < .05), satisfaction with stool consistency (P < .05). On gluten rechallenge after completion of 4 weeks, patient symptom deterioration occurred in days to week duration. ConclusionsOur data identifies a patient population suffering from non-celiac gluten sensitivity. Our data identifies a patient population suffering from non-celiac gluten sensitivity.