Abstract
The Rumack-Matthew nomogram for acetaminophen toxicity was prepared using the acetaminophen levels of untreated patients and published in 1975. In order to determine the risk, the authors aimed to determine the acetaminophen levels that cause the aminotransferase level to increase to 1,000 IU/L and above (1). Thus, the line presenting the values above 200 was created. In the study published by Rumack et al. in 1981, the line representing values above 150 was suggested as a safer value (2). On the other hand, the nomogram was designed on the known intake times of single dose, immediate-release acetaminophen preparations. This causes significant limitations in clinical practice.
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