Abstract
Nanostimulation of single identified neurons in vivo can control spike frequency parametrically and, surprisingly, can even bias the animal's behavioral response. Here, we extend this stimulation protocol to time-dependent broadband noise stimulation in sensory and motor cortices of rat. In response to such stimuli, we found increased temporal spike-time reliability. The information transmission properties reveal, both experimentally and theoretically, that the neurons support high-frequency stimulation beyond the inverse membrane time. Generating a stimulus using the neuron's response properties, we could evoke prescribed spike times with high precision. Our work helps to establish a novel method for precise temporal control of single-cell spiking and provides a simplified biophysical description of single-neuron spiking under time-dependent in vivo-like stimulation.
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