Abstract
The influence of noise on oscillatory motion is a subject of permanent interest, both for fundamental and practical reasons. Cells respond properly to external stimuli by using noisy systems. We have clarified the effect of intrinsic noise on the dynamics in the human cancer cells following gamma irradiation. It is shown that the large amplification and increasing mutual information with delay are due to coherence resonance. Furthermore, frequency domain analysis is used to study the mechanisms.
Highlights
How cells process noise is a challenging problem in illuminating the principle of intracellular motifs [1,2,3]
From the mathematical point of view, the difference between single-cell experiments and cell population experiments of simple regulatory networks arises from stochastic events in individual cells that are averaged out in cell population
Our presented results are crucially relying on coherence resonance, which has been recently studied for temporal systems [54,55,56,57] and spatially extended systems [58,59,60,61,62,63]
Summary
How cells process noise is a challenging problem in illuminating the principle of intracellular motifs [1,2,3]. The large amplification results from the existence of coherence resonance with delay and noise. This initial difference between the particle numbers of chemical species in different cells, which causes the difference in Hill function at later time, is entirely caused by the intrinsic noise.
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