Abstract

Nocardia is a genus of bacteria that can cause infections in human beings as well as animals. It is a typical infection in immunosuppressed patients, although it also affects immunocompetent subjects, particularly its cutaneous form. The main risk factors are chronic lung disease and diseases that induce cellular immunosuppression such as cancers, transplantation, corticosteroid treatment and HIV infection. The most common clinical presentation in our environment is pulmonary. There are also cutaneous and disseminated forms, that target the central nervous system (CNS) in particular, and that result in high mortality. Clinical suspicion is essential for diagnosis, as well as a targeted microbiological study. In vitro susceptibility study is recommended to support the treatment. Cotrimoxazole remains the drug of first choice; however, for serious and/or disseminated forms treatment must include at least two antimicrobial agents that are active against Nocardia. Treatment must be prolonged to prevent relapse.

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