Abstract
Materials and methods : This is an investigation of 49 cases with confirmed ascariasis and pathology of reproductive system in the Lviv City Center for Family Planning and Human Reproduction Lviv Ukraine between January 2013 and December 2015.
 Purpose : The aim of the study was to investigate changes in the L-arginine / NO synthase / arginase system in women with primary infertility and recurrent pregnancy loss with ascariasis presence in Ukraine.
 Results : In women with recurrent pregnancy loss and women with primary infertility were observed significant activation of iNOS in lymphocyte lysates, an increase in nitrite anion production, and a decrease in L-arginine content in the blood plasma and ascariasis compared with RPL and PI patients without ascariasis. 
 Conclusion : Ascariasis can be factor of the development of inflammation.
Highlights
The L-arginine/ NO synthase/arginase system is key in the functioning of endothelial cells and is involved in the regulation of numerous processes in the body, including mechanisms of reproduction [13]
It has been noted that the activity of NO synthase and arginase in peripheral blood lymphocytes changes in conditions of autoimmune diseases in humans [5], and the concentration of L-arginine in blood plasma is significantly reduced upon infection and inflammation [3]
We examined 53 patients with recurrent pregnancy loss (RPL), including 28 women without ascariasis (A) and 25 women with ascariasis, and 51 patients with primary infertility (PI): 27 women without ascariasis and 24 women with presence of acarida invasions
Summary
The L-arginine/ NO synthase/arginase system is key in the functioning of endothelial cells and is involved in the regulation of numerous processes in the body, including mechanisms of reproduction [13]. The balance between the content of L-arginine in the blood plasma and the production of nitrogen oxide by endothelial cells is one of the factors involved in supporting the reproduction processes [15]. Blood lymphocytes maintain the immunological status of the organism due to their phagocytic activity, synthesis of pro- and antiinflammatory cytokines and NO secretion [2], [11], [12]. It has been noted that the activity of NO synthase and arginase in peripheral blood lymphocytes changes in conditions of autoimmune diseases in humans [5], and the concentration of L-arginine in blood plasma is significantly reduced upon infection and inflammation [3]
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