Abstract
This study was conducted to determine the polymorphic allele and genotype frequencies of USF1 306 G>A with homocysteine level and lipid profiles in Bidayuh ethnic group. It aimed to elucidate the association of the polymorphic allele and genotypes with lipid profiles such as total cholesterol (TC), high- density lipoprotein (HDL), low- density lipoprotein (LDL) and homocysteine level in Bidayuh ethnic group in Sarawak. One hundred and forty (140) individuals of the Bidayuh ethnic group were recruited as the study subjects. The Allele Specific PCR (AS-PCR) was used in the genotyping. Association of genotype frequencies and clinical profile was assessed using One Way ANOVA. As for the association of allele frequencies and clinical profile, Independent Sample T test was used. Genotype frequency and allele frequencies of Upstream Transcription Factor 1 (USF 1) 306 G>A not associated with homocysteine level and other lipid profile among Bidayuh ethnic group. Our results show that the genetic diversity of USF1 gene and allele does not influence the susceptibility of homocysteine level among Bidayuh ethnic group of the Malaysian population.
Published Version
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