Abstract
ABSTRACT Introduction: Endometriosis is a common gynecologic disorder influenced by genetic and environmental factors. The glutathione S-transferase family is associated with endometriosis because its main function is cellular detoxification, so the absence of those enzymes may be a factor for the development of the disorder. Objective: Investigate the relationship between polymorphisms of GSTM1 and GSTT1 genes and endometriosis, in order to gain a better understanding of the association between detoxification genes and the susceptibility to endometriosis. Material and methods: Case-control study in 132 women (49 with endometriosis and 83 of the control group). The genotype was determined using multiplex polymerase chain reaction (PCR), observed in 10% polyacrylamide gel electrophoresis stained with silver nitrate, and statistical analysis was performed. Results: There was not a significant difference between the GSTM1 and GSTT1 null genotype in the endometriosis group and the control group (p = 0.9956). The same result was observed with the combined genotype (p = 0.8129). Conclusion: In the present study, the GSTM1 and GSTT1 polymorphisms are not associated with a higher risk of endometriosis.
Highlights
Endometriosis is a common gynecologic disorder influenced by genetic and environmental factors
In order to investigate whether Glutathione S-transferase M1 (GSTM1) and GSTT1 polymorphisms were associated with endometriosis in the Brazilian female population, a comparison was drawn among 132 Brazilian women (49 with endometriosis and 83 of the control group)
Analysis of GSTM1 and GSTT1 polymorphisms showed no significant difference between the study and control groups (χ2 = 0.0001, p = 0.9956, Yates correction p = 0.8611; χ2 = 0.082, p = 0.7740, Yates correction p = 0.9164, respectively) (Table 1)
Summary
Endometriosis is a common gynecologic disorder influenced by genetic and environmental factors. The glutathione S-transferase family is associated with endometriosis because its main function is cellular detoxification, so the absence of those enzymes may be a factor for the development of the disorder. Results: There was not a significant difference between the GSTM1 and GSTT1 null genotype in the endometriosis group and the control group (p = 0.9956). Conclusion: In the present study, the GSTM1 and GSTT1 polymorphisms are not associated with a higher risk of endometriosis. It is a common gynecologic disease that affects 5%-10% of women of reproductive age, but its incidence has been rising in recent years. Endometriosis is considered a complex trait caused by the interaction between genetic[8,9,10] and environmental factors[11, 12]
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