NMR studies of H-D exchange of α-CH group of amino acid residues in peptides

Abstract

The advantages applying NMR techniques to the study of racemization is illustrated and discussed. Using NMR it is possible to measure the rate of racemization of each individual amino acid residue in a peptide. It was found that the rate of racemization depends on the nature of the side chain of the amino acid residue, and on the location of the amino acid in the peptide chain.