Abstract
t[3] – Isopropyl -r[2],c[7]- diphenyl homopiperazin – 5 – one, was prepared using Schmidt reaction. Then, taking the solution of the compound in a suitable solvent, NMR measurements were taken. The chemical shifts were compared with those in CDCl3 . The COSY, NOESY and 13C-1 H correlation spectra had been recorded to assign the signals unambiguously. Coupling constants were calculated using DAERM method and also using the equations of Altona and Karplus for different torsional angles from 0 to 180°. The coupling constants, calculated by Altona’s equation were less than those obtained by Karplus equation for some compounds for a particular range of torsional angles and greater for other range of torsional angles; hence, both Karplus and Altona’s equations can be applied to these compounds satisfactorily. . Keywords: Ammonium Acetate, Ammonia, Anhydrous, Benzaldehyde, Crush, Drop-wise, Extract, Melting Point, Petroleum Ether, Stirring
Highlights
Samples were prepared by dissolving about 10 mg of the compounds in 0.5 ml of DMSO –d6 containg 1% TMS for recording 1 H-NMR and two dimensional NMR spectra
The coupling constants, calculated by Altona’s equation were less than those obtained by Karplus equation for some compounds for a particular range of torsional angles and greater for other range of torsional angles; both Karplus and Altona’s equations can be applied to these compounds satisfactorily
The spectral parameters are given below: 1H NMR ( Plate – 3 ) 13 C NMR ( Plate – 6 ) COSY ( Plate – 4 ) NOESY ( Plate – 2 ) HSQC ( Plate – ) HMBC ( Plate – )
Summary
Samples were prepared by dissolving about 10 mg of the compounds in 0.5 ml of DMSO –d6 containg 1% TMS for recording 1 H-NMR and two dimensional NMR spectra. The COSY, NOESY and 13C-1H correlation spectra had been recorded to assign the signals unambiguously.
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