NMR Spectral Studies of Some Six–membered and Seven–membered Saturated Hetero Cyclic Compounds and Preparation of Some Seven– membered Saturated Hetero Cyclic Compounds and NMR Measurements

Abstract

t[3] - Isopropyl -r[2],c[7]- diphenyl homopiperazin - 5 - one ,were prepared ; Using Schmidt reaction , the compound was prepared. Then taking their solution in a suitable solvent NMR measurements were taken. The chemical shifts were compared with those in CDCl3 . The COSY , NOESY and 13C-1H correlation spectra had been recorded to assign the signals unambiguously. Coupling constants were calculated using DAERM method and also using the equations of Altona's and Karplus , for different torsional angles from 0 to 1800. The coupling constants calculated by Altona's equation were less than those obtained by Karplus equation for some compounds for a particular range of torsional angles and greater for other range of torsional angles ; hence both Karplus and Altona's equations can be applied to these compounds satisfactorily