Abstract
Here, we provide the NMR spectra and AFM data for antioxidant micelles prepared from amphiphilic PAM-PDA block copolymers composed of a poly(N-acryloyl morpholine) and a redox-active catechol-bearing block with different catechol content. We also provide details of the electrochemical analysis that showed micelles higher catechol content had a similar redox potential with the small catechol compound dopamine, but slowed down the redox reaction (Hasegawa et al., Polymer (in press)).
Highlights
We provide the NMR spectra and AFM data for antioxidant micelles prepared from amphiphilic PAM-PDA block copolymers composed of a poly(N-acryloyl morpholine) and a redox-active catechol-bearing block with different catechol content
We provide details of the electrochemical analysis that showed micelles higher catechol content had a similar redox potential with the small catechol compound dopamine, but slowed down the redox reaction (Hasegawa et al, Polymer)
Experimental factors The PAM-PDA block copolymers in DMF were dispersed in acetate buffer followed by dialysis against water to prepare the micelles
Summary
PAM-PDA block copolymers were synthesized as described in Ref [1]. Briefly, N-acryloyl glycine tert-butyl ester was polymerized by reversible addition-fragmentation chain transfer (RAFT) polymerization using 2-(dodecylthiocarbonothioylthio)-2-methylpropionic acid as the chain transfer agent (CTA) and AIBN as the initiator to yield poly(N-acryloyl glycine tert-butyl ester) (3). The CTA end group of polymer (5) was removed by radical-induced reduction to yield polymer (6). This polymer was treated with TFA/H2O to remove the tert-butyl ester groups (polymer (7)). The polymer (7) was reacted with N-hydroxysuccinimide (NHS) in the presence of N,N0-dicyclohexylcarbodiimide (DCC) and thereafter reacted with dopamine (DA) to yield the PAM-PDAx polymer (8). The polymers were analyzed by 1H NMR 1H NMR spectrum of PAG polymer (3).
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