Abstract
Electrical high frequency stimulation is used as treatment for motoric- as well as psychomotoric disorders in various regions of the brain. The biochemical mechanisms of the action of high frequency stimulation underlying the effective results are unclear. Previous studies have demonstrated that electrical 130 Hz stimulation was capable of increasing local γaminobutyric acid outflow in the rat caudate nucleus when neuronal pre-activation was present. In the present study, the local effect of electrical high frequency stimulation on γ-aminobutyric was reviewed under conditions of N-methyl-Daspartate receptor activation. Using in vitro superfusion experiments with tissue slices from the rat caudate nucleus, and colocalized in vivo microdialysis and electrical 130 Hz stimulation of the caudate nucleus in awake and freely moving rats, we can conclude that N-methyl-D-aspartate receptor activation was able to modulate γ-aminobutyric acid outflow induced by electrical high frequency stimulation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
