Abstract
Abstract Natural Killer (NK) cells are the components of innate immune system known for their role in virus infection and tumor immunity. Their importance is appreciated from the case studies where lack of NK cells leads to life threatening herpes virus infection and increased host susceptibility to certain cancers. Recent development in the NK field have opened a new frontier bringing to light that innate immune cells can demonstrate memory features too. In line with the above-mentioned development, we report NK memory cell generation post Zika virus infection in mice. Our detailed transcriptomics, epigenetic and functional analysis revealed that CD27+ memory like NK cell that developed post Zika virus infection exhibited stem cell like properties and shared gene signatures with memory CD8 T cells, stem cells and stem like T cells from chronic infection and cancer. We termed these cells as “NK memory stem cells” which also possessed greater antiviral function when adoptively transferred into Zika infected mice. We next performed single cell RNA-seq on NK memory stem cells and identified multiple subpopulations which differed in gene expression profiles. Our work revealed NK cells with memory like and stemness features that are helpful in fighting viral infection. We also detected subpopulations in NK memory stem cells and efforts are ongoing to evaluate the role of these NK subpopulations in antiviral immunity.
Published Version
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