Abstract
The compound 2-amino-2-deoxyglucitol-6P competitively inhibits E. coli glucosamine-6P synthase with respect to fructose-6P whereas glutamate γ-semialdehyde is a competitive inhibitor with respect to glutamine. These compounds, which exhibit good inhibitory properties ( K m K i = 16 and 1000 respectively), were used in the synthesis of multisubstrate analogs.
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