Abstract
Prestimulation with recombinant-interferon-γ (rIFN-γ) followed by Mycobacterium bovis BCG infection induced high nitric oxide production and potent mycobacterial growth inhibition in murine alveolar macrophages. Reversal of the sequence of treatments caused opposite effects, suggesting that a sequential 2-step process comprising first rIFN-γ stimulation and second mycobacterial infection is operative in the activation of alveolar macrophages.
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