Abstract
Interactions between uric acid and physiologically relevant fluxes of nitric oxide ( NO) during copper-mediated low-density lipoprotein (LDL) oxidation were evaluated. In the absence of NO, a dual pro- and antioxidant action of uric acid was evident: low concentrations of uric acid enhanced lipid oxidation and α-tocopherol consumption, while its protective role was observed at higher concentrations. The prooxidant effects of uric acid were mostly related to its copper-reducing ability to form Cu +, an initiator of lipid oxidation processes. While the prooxidant action of uric acid was completely inhibited by NO, the antioxidant action of NO was slightly counterbalanced by uric acid. Enhancement of α-tocopherol consumption by uric acid was inhibited in the presence of NO while additive antioxidant effects between NO and uric acid were observed in conditions where uric acid spared α-tocopherol. Altogether, these results suggest that in the artery wall, the NO/uric acid pair may exert antioxidant actions on LDL, even if increased amounts of redox active copper were available at conditions favoring prooxidant activities of uric acid.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
