Abstract
The modified low-density lipoprotein (LDL; glycated and oxidized) is more atherogenic and are poorly recognized by LDL receptor. In the present study, an attempt has been made to evaluate the effects of Triphala on LDL modification in experimentally treated rats and in human LDL. The effect of ethanolic extract of Triphala on LDL oxidation susceptibility in high fat diet fed and STZ induced rats was evaluated. The inhibitory effect of Triphala on LDL oxidation and glycation was investigated using copper and glucose induced human LDL, respectively in vitro. The co-presence of Triphala extract significantly increased lag phase and minimized the conjugated dienes formation in dose dependent manner. Copper mediated LDL oxidation was characterized by elevated indices of thiobarbituric acid reactive substance (TBARS), whereas co-presence of Triphala extract significantly minimized the production of TBARS. The results of this investigation shows that Triphala probably with their antioxidant properties inhibited LDL glycation and oxidation and provide scientific reasons regarding the possible medical benefits of using Triphala to prevent diabetic and cardiovascular complications. Key words: Triphala, low-density lipoprotein (LDL) oxidation, LDL glycation, high fat diet, streptozotocin (STZ).
Highlights
Atherosclerosis, a cardiovascular disorder posing main cause for the death in developed as well as developing countries (Stachura and Pierzynowski, 2009).Atherosclerosis is characterized by low-density lipoprotein (LDL) deposition in the arterial wall which ends in the formation of lesions
12 standard deviation (SD) rats were randomly divided into two groups(4 and 5), fed with high fat diet and received Triphala 100 and 200mg/kg of body weight orally along with HFD
LDL oxidation is mediated by free radical and the process is initiated by the removal of hydrogen atom from a methylene (CH2) group of polyunsaturated fatty acids (PUFAs) moiety of LDL
Summary
Atherosclerosis, a cardiovascular disorder posing main cause for the death in developed as well as developing countries (Stachura and Pierzynowski, 2009). Atherosclerosis is characterized by low-density lipoprotein (LDL) deposition in the arterial wall which ends in the formation of lesions. Rupture of lesions clinically leads to heart attack and stroke. Atherosclerosis is a complication associated with diabetes. The risk of atherosclerosis is three to five folds greater than in non diabetics. LDL is a major risk factor in this regard
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