Abstract
This article describes free radical scavenging activity of TEMPO (2, 2, 6, 6-tetramethylpiperidin-1-yloxyl) radical functionalized dendrimers of generation G0 - G4 against nitric oxide (NO), 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) radicals. The total antioxidant activity of the dendrimers was also reported and compared with pure 4-hydoxy TEMPO (constituent of dendrimers) and ascorbic acid (vitamin C) standard. The activity of TEMPO functionalized G4 dendrimer against scavenging of nitric oxide and hydrogen peroxide radicals was found comparable to vitamin C. The data presented in this article supports the good antioxidant activity of the dendrimers newly reported in our previous publication (Radical dendrimers: Synthesis, anti-tumor activity and enhanced cytoprotective performance of TEMPO free radical functionalized polyurethane dendrimers).
Highlights
Nitric oxide, diphenyl picrylhydrazyl (DPPH) and hydrogen peroxide radical scavenging activity of TEMPO terminated polyurethane dendrimers: Data supporting antioxidant activity of radical dendrimers
Free radical scavenging capability of TEMPO functionalized dendrimers against nitric oxide radical (NO), DPPH radical and hydrogen peroxide as well as total antioxidant activity of dendrimers were examined at 200mg/mL concentration of each sample
Data on antioxidant activity of radical dendrimers against different radical species were collected according to reported procedures [2e5] and compared with Vitamin-C
Summary
Materials science Biomaterials Table, Graph Data were generated using UVeVis spectrophotometer (Agilent 8453 UVeVis diode array spectrophotometer) and standard experimental procedures. Free radical scavenging capability of TEMPO functionalized dendrimers against nitric oxide radical (NO), DPPH radical and hydrogen peroxide as well as total antioxidant activity of dendrimers were examined at 200mg/mL concentration of each sample. Data on antioxidant activity of radical dendrimers against different radical species were collected according to reported procedures [2e5] and compared with Vitamin-C. Value of the Data The data represent free radical scavenging capability of synthesised radical dendrimers and are basis for therapeutic evaluation of the compounds. Researchers studying oxidative stress in the cellular system and age related disease can benefit from these data. These data will be useful for the development of anti-aging drugs for age related disease through therapeutic evaluation
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