Abstract
Nipple Inflammation: An Unusual Adverse Effect from Vemurafenib, A V600E BRAF Inhibitor during Off-Lable Treatment for Anaplastic Thyroid Carcinoma
Highlights
Case PresentationVemurafenib is a monoclonal inhibitor of a mutant tumor tyrosine kinase protein, V600 E, produced by certain malignant tumors such as advanced cutaneous melanoma, adenocarcinoma of the colon, and anaplastic thyroid cancer
3 cutaneous toxicity consisting of facial sensation of warmth and flushing, pruritis, extensive xerosis, folliculocentricexanthums, and painful, nipples accompanied by an uncomfortable burning sensation exacerbated by contact with undershirts and bedsheets
New Findings: Nipple inflammation should be added to the list of adverse dermatological effects of vemurafenib
Summary
Case PresentationVemurafenib is a monoclonal inhibitor of a mutant tumor tyrosine kinase protein, V600 E, produced by certain malignant tumors such as advanced cutaneous melanoma, adenocarcinoma of the colon, and anaplastic thyroid cancer. 3 cutaneous toxicity consisting of facial sensation of warmth and flushing, pruritis, extensive xerosis, folliculocentricexanthums, and painful, nipples accompanied by an uncomfortable burning sensation exacerbated by contact with undershirts and bedsheets. Administration of triamcinolone cream (0.1%, twice daily) rapidly eliminated the pain and burning sensation from his nipples.
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