Abstract
BackgroundEndometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk.MethodsFive SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis.ResultsThe SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR 1.46, 95% CI 1.04–2.06, p = 0.028; OR 8.43, 95% CI 1.05–67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls.ConclusionThe NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.
Highlights
Endometrial cancer is malignant tumor of endometrium epithelial, which is one of the most common female reproductive system tumors [1]
We found compared with common G allele, the rs118050317 C allele were significant increased 0.46-fold endometrial cancer risk
After adjusted the age, compared with GG genotype carriers, the rs118050317 CC genotype carriers were significant increased the endometrial cancer risk under co-dominant model, the results significant under log-additive model (Additional file 1: Table S2)
Summary
Endometrial cancer is malignant tumor of endometrium epithelial, which is one of the most common female reproductive system tumors [1]. Increased estrogen exposure is a major risk factor for endometrial cancer, early menarche, infertility, obesity and late menopause are associated with endometrial cancer risk, too [5]. Women with a family history of endometrial cancer have a higher risk of the disease than those without a family history, suggesting that inherited genetic factors have an impact on the incidence of endometrial cancer [6]. In the genome-wide association study of endometrial cancer, the susceptibility locus close to HNF1B on chromosome 17q was associated with endometrial cancer [7]. Five endometrial cancer risk SNPs loci on 13q22.1, 6q22.31, 8q24.21, 15q15.1 and 14q32.33 were identified by genome-wide association study [9, 10]. Endometrial cancer is one of the most common female reproductive system tumors. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
