NIMG-72. A NOVEL ARRAY LAYOUT FOR DELIVERING TTFIELDS TO THE WHOLE BRAIN

Abstract

INTRODUCTION: Tumor Treating Fields (TTFields) is an antimitotic cancer treatment approved for the treatment of Glioblastoma Multiforme. TTFields are delivered using 2 pairs of transducer arrays. When treating Glioblastoma, the array positioning on the head is planned to maximize TTFields dose delivered to the tumor. This results in an increased dose of TTFields at the tumor, whilst reducing the intensity of the field in other regions. In some clinical scenarios, such as treatment of multiple brain metastases, it might be desirable to deliver TTFields at therapeutic intensities to the entire brain, thereby ensuring that even microscopic lesions receive a therapeutic dose of TTFields. Here we present novel transducer array layouts designed to deliver a uniform distribution of TTFields to the entire brain. Methods Computer simulations were used to calculate the field distributions generated by different array layouts. The simulations utilized a realistic computerized head model of a 40+ years old human mal. Delivery of TTFields using pairs of array layouts placed at different locations on the head and neck was simulated using Sim4Life V3.0 (ZMT Zurich). To analyze the field distributions, the brain was divided into five regions: 1) the cerebellum, brain stem and other infra-tentorial anatomical regions; 2–5) four quadrant of the cerebrum. The mean and median field intensities in the five regions generated by each layout were calculated and compared. Results A layout in which one pair of arrays is placed on the right temple, and left scapula and the second pair placed on the left temple and right scapula yielded a uniform intensity distribution within the brain. (median intensities between 1.5 V/cm to 1.7 V/cm within all regions). Conclusion We have identified a novel TTFields array layout that will be beneficial in clinical scenarios where treatment of the entire brain with TTFields is desired.