Abstract
Objective: Impairment of night-to-day blood pressure (BP) ratio led to an increase in cardiovascular outcomes. The aim of the present study was to examine night-to-day BP ratio variability in two repeated 7 day/2h ambulatory BP monitoring (AMBP) in patients with coronary heart disease (CHD). Design and method: The 20 patients with CHD were under therapy with ACE inhibitors, beta blockers and statins. The AMBP was in every patient provided twice and AMBP lasted 7 days/ 24-h repeatedly. The 20 patients were divided in subgroup 1 and 2. Subgroup 1 was monitored before and after 3months of cardiovascular rehabilitation 3 times a week. Subgroup 2 was monitored before and after usual every day activity. We evaluated night-to-day BP ration in 24-h in BP profile and 7 day mean value before and after cardiac RHB in SBP and DBP in subgroup 1 and also subgroup 2. Results: The mean values of night-to-day in SBP ration evaluated from 7 day/24-h AMBP in subgroup 1 with cardiovascular rehabilitation in the 1st monitoring: was 12.0±1.85%, in 2nd AMBP 8.4±1.89% (not significant). The mean values of night-to-day DBP ratio evaluated from 7 day/24-h AMBP in subgroup 1was in 1st monitoring: was 13.7±1.54%, in 2nd monitoring was 11.4±1.34% (not significant). The mean value of night to day SBP ratio evaluated from 7 day/24 hour AMBP in subgroup 2 was 1st monitoring was 17.3±2.23%, in 2nd monitoring was: 18.8±1.16% (not significant). The mean values of night to day DBP ratio evaluated from 7 day /24 hour AMBP in subgroup 2 was in 1st monitoring was 19.6±2.66%; 2nd monitoring: 20.7±1.33% (not significant). Conclusions: In patients with CAD night-to-day BP ration from 7 day/24 h AMBP varied in one BP in 24-h profile and also in mean values from 7 day/24-h AMBP in both subgroups in values from1st and 2nd BP measurement. We have not found significant difference between the subgroup 1 before and after cardiac rehabilitation. We have not found significant difference in repeated measurement in subgroup 2 with usual activities between repeated measurements.
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