Abstract

AbstractPenta-1,4-diyn-3-ol–Co2(CO)6 complexes undergo Lewis acid mediated Nicholas reactions with high selectivity at the C-3 site, to give skipped (1,4-)diyne complexes. The compatible nucleophiles have a wide range of reactivity. The methodology has been applied to the synthesis of both (E)- and (Z)-isomers of a hinokiresinol and nyasol analogue, the (E)-isomer of which is known to have elevated antiplasmodial and antimalarial activity.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call