Abstract
In this study, CQDs-SiO2@MIP fluorescence sensor was fabricated via sol-gel polymerization using naproxen as the template molecule, carbon quantum dots (CQDs) as the signal materials, 3-aminopropyltriethoxysilane (APTES) as the functional monomer, and tetraethylorthosilicate (TEOS) as the cross-linker. The specific recognition sites in the polymer layers could selectively adsorb naproxen molecules, which caused fluorescence-quenching behavior of CQDs via an electron transfer process. The CQDs-SiO2@MIP system can detect naproxen in aqueous solution (pH 4.0; Acetate buffer 0.04M) sensitively (ppb level) with a response time of 15 min. The results show that the fluorescence recovery has a good linear relationship with Naproxen concentration in the range of 10-7 M to 1.5 10-7 M. Method has very low limit of detection (LOD) of 5 10-8M (11 ppb), limit of quantitation (LOQ) of 1.5 10-7M (34 ppb), high accuracy (recoveries > 96%) and high precision (RSD < 3%). Method has high selectivity over various substances such as K+, Mg2+, Ca2+, Zn2+, glucose, piroxicam, acid mefenamic,… The developed method was successfully applied for determination of naproxen in pharmaceutical samples. Good agreement between results of our method and LC-MS/MS method suggest that fluorescence is a reliable and cost-effective method for naproxen determination.
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