Abstract
Multiple myeloma (MM) is characterized by high genetic heterogeneity, which in turn affects not only the development of the disease but also the therapeutic response. To further characterise the genetic heterogeneity in MM, we applied a novel approach of next-generation optical mapping to study a genomic architecture of MM cells. We analysed samples of bone marrow from two patients with newly diagnosed MM using optical mapping together with standard Methods (karyotype, FISH, and arrayCGH) and compared the Results of these approaches.
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