Newly developed nonalcoholic fatty liver disease after pancreaticoduodenectomy

Abstract

Objective To study risk factors of newly developed nonalcoholic fatty liver disease (NAFLD) in patients after pancreaticoduodenectomy (PD) and the effect on prognosis. Methods Date of patients undergoing PD surgery at Pancreatic Department, Tianjin Cancer Hospital were collected from Jan 2016 to Dec 2016. Patients were divided into two groups according to occurrence of NAFL Devents. Results There were 22 patients in NAFLD group (group Ⅰ) and 47 patients in non NAFLD group(group Ⅱ). All patients were followed up till the end of 2017.Multi-factor analysis showed that extraintestinal drainage of pancreatic juice (OR=18.118, 95% CI 2.968-114.455, P=0.002) and dissected lymph node number over 30 (OR=8.424, 95% CI 2.272-31.232, P=0.001)were independent factors associated with NAFLD in patients after PD. Survival analysis showed no statistically significance for median progression-free survival (12.7 months in group Ⅰ vs.13.9 months in group Ⅱ, P=0.99) and median overall survival (mOS) (15.4 months in group Ⅰ vs.17.7 months in group Ⅱ, P=0.09). Conclusions Extraintestinal drainage of pancreatic juice and lymph node clearance over 30 are independent risk factors for new NAFLD in PD patients. The effect of new NAFLD on PFS and OS is not statistically significant. Key words: Pancreatoduodenectomy; Fatty liver; Risk factors; Survival analysis