Newly Developed Embolic Material Mesosphere and Titanium

Abstract

To date, various particulate embolic materials have been developed and investigated experimentally, but none have reached a stage where they are permanently suitable for routine clinical application. The particles should have a non-absorbable character and good biocompatibility. ES particles (ES; BioSphere Medical, MA) fulfill these general requirements. The particles should be spherical so that they can be sorted into various sizes by sieving, providing uniformly graded and calibrated material. Spherical particles provide geometrically optimal occlusion of the vascular lumen. They are hydrophilic, non-absorbable, collagen-coated, acrylic microspheres. Distal portions of the microvasculature can be reached by the microspheres. PVA particles have been the most commonly used for embolization 5. Embolization experiments were independently conducted in an animal model using a combination of ES. However, this embolic material is not radiopaque. We thought that combining it with titanium could solve this problem. Pure titanium is radiolucency material. Before clinical use, we investigated ES experimental study using combination with titanium. In this paper, we report the clinical application of ES compared with PVA in the embolization of meningiomas.