New Treatment of Alzheimers Disease

Abstract

Alzheimers disease is a major degenerative disease characterized by impaired memory, aphasia, apraxia and the changes of personality and behavior. As the population ages, the incidence of AD is increasing. According to an analysis of 10000 people with up to 30 years of follow-up data, elderly over 55 years old, the risk of dementia increased nearly four- fold if they have three or more chronic diseases at the age of 55. The pathogenesis of AD has not been fully studied, a lot of mechanisms such as neuroinflammation, mitochondrial dysfunction, abnormal metabolic are related to the pathology of AD. The abnormal deposition of A and hyperphosphorylation of Tau protein are identified mechanism of AD. Finding new drugs for AD has always been a research hotpot, preclinical work of new anti-AD drugs is being carried out on a large scale in the world. However, in all types of new developing drugs for AD, the failure rate is about 99%. The drugs approved to treat AD such as acetylcholinesterase inhibitors and glutamate receptor antagonists, only slow symptoms other than change the progression of this disease. Deep researches are required to study the pathogenesis of AD, developing drugs that can reverse the progression is the key to the treatment for AD. This review introduces new developing therapy and potential targets of future research into treatments of AD.