Abstract
To study the performance of a new method designed to measure discrepancy between real prescriptions and evidence-based reference treatments. Two different indices (additive and multiplicative) are proposed to summarize deviation between prescription and reference. Deviations thought to be observed in a population of prescribers are simulated in diverse hypothetical situations in the presence or absence of evidence-based references. The performances of both indices are compared and their sensitivities to change are explored. Both indices are sensitive to variation in prescriber behaviour. The additive index allows a more accurate analysis of deviation while the multiplicative index is simpler to implement and interpret but more sensitive to change. The two deviation indices may be used as new tools in surveys or trials dealing with prescribing practices.
Published Version
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