New tools for evidence-based risk assessment of chemical mixtures

Abstract

s / Toxicology Letters 229S (2014) S4–S21 S19 extended beyond metabolic interactions, into the realm of cellular effects. http://dx.doi.org/10.1016/j.toxlet.2014.06.099 PS7.1-O3 New tools for evidence-based risk assessment of chemical mixtures Billy Amzal1,∗, Nadia Quignot1, Jean-Lou Dorne2, Frederic Bois3,4, Camille Bechaux2 1 LASER Analytica, Paris, France, 2 EFSA, Parma, Italy, 3 UTC, Compiegne, France, 4 INERIS, Verneuil en Halatte, France Risk assessment of chemical mixture has brought a number of scientific challenges, e.g. with respect to relevant data collection and robust quantitative methods to assess risks in humans. In this talk, the challenges will be presented in both regulatory and scientific viewpoints. Then, new tools for evidence-based risk assessment of chemical mixtures will be discussed in the context of the application of the systematic reviewmethodology andmetaanalysis to integrate metabolic interactions and toxicodynamic interactions for substances of priority in the food safety area. Examples of applicationandperspectives for embedding such techniques in routine risk assessment bodies will be presented. http://dx.doi.org/10.1016/j.toxlet.2014.06.100 PS7.1-O4 Harmonisation of ecological and human risk assessment of chemical mixtures