New Thiazolyl Azo Ligand and Its Co(III), Cd(II) Complexes: Synthesis, Characterization, Cytotoxic and Computational Studies

Abstract

A novel 2- [-2-(4, 5-dimethyl thiazolyl) azo] -5-dimethyl amino benzoic acid) was synthesized from 2-amino-4,5- dimethyl thiazole. The azo ligand was obtained by the diazotization of 2-amino-4,5- dimethyl thiazole and coupling with 3-dimethyl amino benzoic acid in an alkaline alcoholic solution. Compounds were characterized by spectroscopic methods such as (1H, 13C NMR, UV–Vis, FT-IR) mass spectra, and XRD diffraction. In addition to, standard characterization techniques that including elemental analysis, thermal gravimetric analysis, molar conductivity, and FESEM. These studies revealed octahedral geometries around the Co(III) and Cd(II) ions. The prepared compound was a screen for their bioactive such as streptococcusEscherichia coli, and Penicillium.sp. Moreover, Anticancer activity of the new ligand and Co complex was tested against breast carcinoma cell (MCF-7) cell lines by MTT assay and results revealed that the synthesized complex exhibited a good anticancer activity a promising candidate for future anti-cancer drugs. Also, the theoretical section was used to determine the physical characteristics and inhibitory activity of cancer cells via docking.