Synthesis, characterization, cytotoxic, and computational studies of new complexes (copper and cadmium)

Abstract

A novel 2- [-2-(4, 5-dimethyl thiazolyl) azo] -5-dimethyl amino benzoic acid was synthesized from 2-amino-4,5- dimethyl thiazole. The azo ligand was obtained by the diazotization of 2-amino-4,5- dimethyl thiazole and coupling with 3-dimethyl aminobenzoic acid in an alkaline alcoholic solution. The compounds were characterized by spectroscopic methods such as 1H, 13C NMR, UV–Vis, FT-IR, mass spectroscopy, and X-ray diffraction. In addition, standard characterization techniques including elemental analysis, thermogravimetric analysis, molar conductivity, and FESEM were employed for characterization. These studies revealed octahedral geometries around the Co(III) and Cd(II) ions. The prepared compounds were screened for bioactivity against Streptococcus, Escherichia coli, and Penicillium. sp. MTT assay demonstrated that the synthesized compounds had excellent anticancer activity against the breast carcinoma cell lines (MCF-7), proposing them as a suitable candidate for future anticancer therapies. Docking was also employed to evaluate the cancer cells' physical properties and the inhibitory action of the synthesized compounds against the cancer cells.