Abstract
99mTc-Labeled antimony trisulfide (ATS) colloid is a radiopharmaceutical that can be useful in evaluation of the patients with breast cancer. The existing 99mTc-ATS preparation method involves a lengthy procedure of boiling on a water bath; the recommended quality control procedure is also rather laborious and time consuming. Using a microwave oven, the heating time necessary to provide a maximum labeling efficiency can be reduced to 15 sec. A new minipaper chromatography (MPC) system involving two developing solvents has been developed to analyze the radiochemical purity (RCP) of the labeled preparation. The conventional thin layer chromatography (TLC) system involving the use of an Al2O3 coated plate requires an average time of 38.4 ± 0.21 min (n = 30) for complete drying and development, whereas the new MPC system has an average development time of 4.1 ± 0.32 min (n = 20). In the RCP evaluation, the MPC and TLC methods give closely correlated results (r = 0.94). The combined use of the proposed microwave heating technique and the rapid MPC quality control system facilitate the emergency use of 99mTc-ATS colloid diagnostics.
Published Version
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