Abstract
Background: Insulin resistance is the pathophysiological basis of several cardiometabolic risk conditions. The early identification of insulin resistance decreases the risk of cardiometabolic complications. The correlation between the increase in visceral fat, central obesity and with insulin resistance is a important indicator. Present study was conducted to find the correlation between various anthropometric measurements and insulin resistance (HOMA-IR) and to find out the anthropometric marker, which correlates most significantly with insulin resistance.Material and methods: This is a population based cross-sectional study. Total 100 apparently healthy subjects (n=55 male and n=45 female) aged between 18-25 years were recruited with prior ethical approval and with written informed consent .All the anthropometrical measurements were done as per the standard methods. Fasting glucose and insulin were estimated by using commercially available kit. Insulin resistance was quantified using homeostasis modelResults: There was positive correlation between HOMA-IR and waist circumference (r=0.395, p=0.0001). However, significant positive & mild correlation between HOMA-IR and waist hip ratio was found (r=0.263, p =0.008). The correlation between HOMA-IR and waist height ratio was also observed to be positive and moderate.Conclusion: As per the findings we concluded that, waist circumference and waist height ratio are better predictors of insulin resistance compared to the other anthropometric measurements in apparently healthy north Indian subjects.
Highlights
Insulin resistance (IR) syndrome is one of the important risk factor for cardiovascular diseases[1,2,3,4,5,6,7]
The correlation analysis reveals that the Body mass index, Waist circumference, Waist-hip ratio and Waist-Height ratio were positively correlated with homeostasis model assessment (HOMA)-IR an index of insulin resistance
Insulin resistance causes the metabolic alterations that results in metabolic syndrome (MetS)[23,24,25,26,27] and prevalence of MetS is directly proportional to the obesity[28,29,30]
Summary
Insulin resistance (IR) syndrome is one of the important risk factor for cardiovascular diseases[1,2,3,4,5,6,7]. The laboratorial methods for the determination of insulin resistance are expensive and with standardization deficiencies for its execution, limiting its application in clinical practice [8]. Indirect methods have been developed, out of which homeostasis model assessment (HOMA) index is one of the most commonly used method to assess the insulin resistance. This index shows a good correlation to the clamp procedure[9]. Insulin resistance was quantified using homeostasis model Results: There was positive correlation between HOMA-IR and waist circumference (r=0.395, p=0.0001). Conclusion: As per the findings we concluded that, waist circumference and waist height ratio are better predictors of insulin resistance compared to the other anthropometric measurements in apparently healthy north Indian subjects.
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