Abstract
We present a new method for creating conditions conducive to axonal growth in injured optic nerves of adult rabbits. The surgical approach consists of making a cavity in the adult rabbit optic nerve, into which a piece of nitrocellulose soaked with conditioned medium originating from regenerating fish optic nerves is implanted. In addition, daily irradiation (10 days, 5 min, 35 mW) with low energy He-Ne laser is carried out. Such a combined treatment may open a door to neurobiologists and clinicians, hoping to unravel the enigma of mammalian CNS regeneration.
Highlights
Mammalian central nervous system (CNS)neurons have a negligible capacity to regenerate after lesions/5,6,8,12/
Central nervous system neurons of lower vertebrates reliably regenerate after axotomy
Studies carried out by several research groups/1,16/, as well as by the group of Schwartz et al./7,13/, have led to the prevailing hypothesis that axotomized neurons, mammalian as well as nonmammalian, are capable of regenerating their injured axons, but the success or failure of the regeneration process depends upon the response of the nonneuronal cells to the injury /1,7,13L it is reasonable to assume that immediately after injury, neurons enter a mode of growth which will be expressed only if the environment of these axons is simultaneously conducive for axonal growth
Summary
Mammalian central nervous system (CNS)neurons have a negligible capacity to regenerate after lesions/5,6,8,12/. Central nervous system neurons of lower vertebrates reliably regenerate after axotomy. Optic nerve injury in mammals results in a failure of the surviving cells to regrow their axons and to death of most of the axotomized neurons. Studies carried out by several research groups/1,16/, as well as by the group of Schwartz et al./7,13/, have led to the prevailing hypothesis that axotomized neurons, mammalian as well as nonmammalian, are capable of regenerating their injured axons, but the success or failure of the regeneration process depends upon the response of the nonneuronal cells (astroeytes, oligodendroeytes, microglia cells) to the injury /1,7,13L it is reasonable to assume that immediately after injury, neurons enter a mode of growth which will be expressed only if the environment of these axons is simultaneously conducive for axonal growth
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