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Abstract
Objective: The objective of this study was to study the antimicrobial activity of topical photodynamic therapy (PDT) on chronic skin ulcers infected with Pseudomonas aeruginosa (PA). Methods: Patients with chronic skin ulcers in lower limbs infectedwith PAwere enrolled. The surface areas of the ulcerswere treatedwith either a combination of aminolevulinic acid (ALA) and red light (ALA PDT) or red light alone, both once aweek for 2weeks. Results: At 24h post treatment, although the bacteria levels in two groups were similar (p<0.05), the reduction in ALA PDT group was more significant (p<0.01). At seven days post treatment, the mean ulcer area in the red light group was reduced 45%, that of the PDT group 73% (p<0.01). Conclusion:ALA PDT is a potentialmodality to control PA infection and promote healing of chronic skin ulcers in lower limbs.
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