Abstract
3-(2,3-Dihydroxy-propoxy)-propyl-silica (diolsilica) was modified to bonded stationary phases for normal-phase high-performance liquid chromatography (NPLC) carrying phosphorous ester, boronic ester, and nitric acid ester groups. The NPLC phases were investigated with respect to their properties towards separations of polyaromatic hydrocarbons, and chlorinated and nitrated environmental pollutants. Aminopropyl-silica and nitrooxy-propyl-silica (the latter synthesized in our working group) are presented for comparison. Depending on the functionality used for the modification the retention behavior can significantly be changed towards the three analyte classes. Especially 2,2,2-tribromoethyl-phosphoromorpholino-chloridate modified diol-silica, 2,2,2-tribromoethyl-dichlorophosphate modified diol-silica and nitrated diol-silica (nitrooxy-propoxypropyl-silica) show specific properties for the separation of polyaromatic hydrocarbons, chlorinated analytes and nitrated analytes. Preparation and packing of the adsorbents are described. Principal Component Analysis (PCA) is used as a chemometric tool for effective data reduction and visualization of the results in terms of retention behavior of the stationary phases.
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