Abstract
Abstract Two new Ru(II) complexes containing tris(2-pyridylmethyl)amine was synthesised by reacting [RuCl2 (EPh3)3] E = P, As with TPA.3HClO4 in 1:1 ratio. The new complexes were characterized by various spectroscopic (IR, UV–Vis and NMR) techniques and the structure of the complexes was confirmed by X-ray crystallography. Crystallographic studies of the complexes 1 and 2 revealed the octahedral geometry around ruthenium ion. The binding ability of the complexes with CT-DNA was carried out by photophysical (absorption/emission titration) methods in which an intercalative mode of binding was observed. Further, their ability to interact with BSA protein has been explored. Investigations of antioxidant properties showed that all the compounds have significant radical scavenging properties. The anticancer activity of the Ru(II) complexes was probed in vitro cytotoxicity against human breast (MCF7) and lung (A549) cancer cell lines by MTT assay and cytological changes observed in (AO/EB and DAPI) staining method. The compounds showed significant activity in the biological studies.
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